The role of sirtuins in tendinopathy

Tendinopathies are a group of diseases causing pain or injury to tendons. At the basis of a tendinopathy there is a trauma or a functional overload of a suffering tendon: the mechanical stress triggers micro-traumatic events, which becomes pathologies when the traumatic events causing degeneration of the tissue predominate the regeneration processes. Sirtuins are histones […]

The role of group B vitamins in neuroprotection

The incidence of cognitive impairment and dementia increases with aging, so it is of much interest to identify and target the risk factors, with the aim of slowing or prevent the cognitive impairment age-related. Numerous studies correlate the group B vitamins shortage to phenomena involved in Alzheimer disease pathogenesis and other neurodegenerative diseases. In literature, […]

PEA and intestinal health

Palmitoylethanolamide (PEA) is an endogenous fatty acid amide, synthetized by immune and nervous cells and it is involved in chronic pain and inflammation signaling: endogenous PEA levels increase in response to external stresses, but in chronic condition they can be inadequate to maintain homeostasis, so there is the possibility to administer exogenous PEA, with analgesic […]

NMN and mild cognitive impairment: an innovative approach

Mild Cognitive Impairment (MCI) is the pre-clinical phase between healthy aging and dementia; it is characterized by mild alteration in the cognitive functions, which do not interfere with the daily life and usual activities. It is estimated that 19% of the over-65 is affected and 46% of these cases evolve in dementia in the following […]

Probiotics to treat Irritable Bowel Syndrome

Irritable Bowel Syndrome (IBS) is a gastrointestinal disorder, not associated to structural or biochemical alteration, chronic, with abdominal pain, recurrent uneasiness, altered intestinal motility, with diarrhea, constipation and bloating as recurrent symptoms. IBS cases diarrhea if the intestinal motility is increased, causing a lower water absorption from the gut; meanwhile it causes constipation if the […]

The role con Coenzyme Q10 in the neurological health

Coenzyme Q10 (CoQ10) is fundamental for the proper working of the mitochondria, intracellular organelles for energy production. Since CoQ10 promotes the ATP production in presence of oxygen, it is essential to maintain a good physical efficiency. Interestingly, CoQ10 concentration decreases with age and lower levels are recorded in patients affected by neurological diseases; as shown […]

The role of sirtuins in osteoarthritis

Osteoarthritis (OA) is degenerative bone joint disease, a tough but elastic material which coats the end of the bones, reducing friction, increasing the ability to cushion impacts and improving the joint overall functionality. Sirtuins are histones deacetylases NAD+ dependent, which regulate many important metabolic pathways and are involved in many biological processes, such as cell […]

Statins and Coenzyme Q10

Statins are the most effective treatment to reduce cholesterol in blood available at the moment, so they are considered a good help to reduce the incidence of serious cardio-vascular diseases. Statins are present in nature and they are produced by some mushrooms; now, non-natural statins are used, they are chemically synthetized, to produce drugs and […]